Kazuo Tsubota and his team reported the natural carotenoid crocetin to suppress experimental myopia in mice. Now we evaluated the effects of crocetin on myopia suppression in children. In this multicenter randomized double-blind placebo-controlled clinical trial was performed with 69 participants aged 6 to 12 years, whose cycloplegic spherical equivalent refractions (SER) were between -1.5 and -4.5 diopter (D).